研发生产氯哌酮芬地唑 氯哌斯汀芬地柞酸 氯哌斯汀芬地柞酸盐CAS: 85187-37-7吨位出货优势供应现货直销

中文名氯哌斯汀芬地柞酸盐英文名o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)别名氯哌酮芬地唑氯哌斯汀芬地柞酸氯哌斯汀芬地柞酸盐氯苄哌醚联苯酰苯酸盐化合物 T136191-(2-((4-氯苯基)(苯基)甲氧基)乙基)哌啶 2-(6-羟基-[1,1'-联苯]-3-羰基)苯甲酸盐英文别名Cloperastine FebdizoateCloperastine fendizoateLevocloperastine FendizoateLevocloperastine Fendizoate Racemic Impurity1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine Fendizoate1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,2-(4-hydroxy-3-phenylbenzoyl)benzoic acidCAS85187-37-7EINECS286-126-9化学式C40H38ClNO5分子量648.18642InChIInChI=1/C20H24ClNO.C20H14O4/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;21-18-11-10-14(12-17(18)13-6-2-1-3-7-13)19(22)15-8-4-5-9-16(15)20(23)24/h1,3-4,7-12,20H,2,5-6,13-16H2;1-12,21H,(H,23,24)熔点185-187°C沸点593.9°C at 760 mmHg闪点327°C蒸汽压5.95E-15mmHg at 25°C溶解度DMSO (微溶) 、甲醇 (微溶)存储条件Hygroscopic, -20°C Freezer, Under inert atmosphere稳定性吸湿性外观固体颜色White to Off-White体外研究Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with IC 50 value of 27±3 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.体内研究In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.

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