研发生产咳平盐酸盐 盐酸氯哌丁 盐酸氯哌斯丁 盐酸氯哌斯汀CAS: 14984-68-0吨位出货优势供应现货直销

中文名盐酸氯哌斯汀英文名cloperastine hydrochloride别名咳平盐酸盐盐酸氯哌丁盐酸氯哌斯丁盐酸氯哌斯汀氯哌斯汀盐酸盐盐酸氯哌丁(咳平)CLOPERASTINE HYDROCHLORIDE 氯哌斯汀盐酸盐英文别名Sekiht11hustazolUNII-PI4N7C63NDCloperastine HClcloperastinacloridratoCloperastina cloridratocloperastine hydrochlorideCHLOPERASTINE HYDROCHLORIDECloperastina cloridrato [Italian]2-piperidinoethylp-chlorobenzhydryletherhydrochloride2-Piperidinoethyl p-chlorobenzhydryl ether hydrochloride4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato1-(2-(p-Cloro-alpha-fenilbenzilossi)etil)piperidina cloridrato1-(2-((4-Chlorophenyl)phenylmethoxy)ethyl)piperidinium chloride1-(2-((4-Chlorophenyl)(Phenyl)Methoxy)Ethyl)Piperidine Hydrochloride1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride1-(2-((p-Chloro-alpha-phenylbenzyl)oxy)ethyl)piperidine hydrochloride1-(2-(p-Cloro-alpha-fenilbenzilossi)etil)piperidina cloridrato [Italian]Piperidine, 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-, hydrochloridePiperidine, 1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)-, hydrochloride (9CI)CAS14984-68-0EINECS239-067-8化学式C20H25Cl2NO分子量366.32InChIInChI=1/C20H24ClNO.ClH/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;/h1,3-4,7-12,20H,2,5-6,13-16H2;1H熔点147.9°沸点423.9°C at 760 mmHg闪点210.2°C蒸汽压2.15E-07mmHg at 25°C溶解度DMSO (微溶) 、甲醇 (微溶)存储条件Inert atmosphere,Room Temperature外观整洁颜色White to Off-WhiteMerck14,2395体外研究Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.体内研究In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.

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