研发生产卡非左米 卡菲佐咪 卡菲佐米CAS: 868540-17-4原料药研发供应中间体现货直销

中文名卡非佐米英文名Carfilzomib别名卡非左米卡菲佐咪卡菲佐米卡非佐米卡非佐米APIPROTEASOMEL抑制剂卡非佐米, 不可逆蛋白酶体抑制剂卡非佐米CARFILZOMIB(PR-171)(S)-2-((S)-2-(2-(2H-1,4-恶嗪-4(3H)-基)乙酰氨基)-4-苯基丁酰胺)-4-甲基-N-((S)-1-((S)-4-甲基-1-((R)-2-甲基环氧乙烷-2-基)-1-氧代戊烷-2-基氨基)-1-氧代-3-苯基丙-2-基)戊酰胺英文别名PR 171PX-171-007CarfilzomibCarfilzoMib saltPR-171 (CarfilzoMib)Carfilzomib API and intermediates(alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-phenylalaninamideN-{(2S)-2-[(Morpholin-4-ylacetyl)aMino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-Methyl-1-[(2R)-2-Methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninaMideN-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide(S)-2-((S)-2-(2-(2H-1,4-oxazin-4(3H)-yl) acetamido)-4-phenylbutanamide)-4-methyl-N-((S)-1-((S)-4-methyl-1-((R)-2-methyl oxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)pentanamideCAS868540-17-4EINECS692-054-2化学式C40H57N5O7分子量719.92InChIInChI=1/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1密度1.161熔点204 - 208°C沸点975.6±65.0 °C(Predicted)闪点543.8℃蒸汽压0mmHg at 25°C溶解度Soluble in DMSO (up to 80 mg/ml) or in Ethanol (up to 25 mg/ml).折射率1.551酸度系数13.17±0.46(Predicted)存储条件-20°稳定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.外观solid颜色White